Endocrine Abstracts

Introduction: De la Chapelle syndrome (46XX male syndrome) is a rare anomaly with the characterstics of discordant chromosomal and gonadal sex. Individuals with classical 46XX male sex reversal syndrome have an apparently normal male phenotype and presents with infertility or sub-fertility.Case report: Twenty five year old male, married 2 years back, came to take opinion regarding his Infertility. He is a healthy looking male with well developed secondar...

We have previously described a series of patients who presented with clinical and biochemical features diagnostic of phaeochromocytoma but in whom catecholamine excess proved to be secondary to undiagnosed obstructive sleep apnoea (OSA). We describe here a prospective study of 30 patients presenting to the sleep clinic with OSA from whom 24 hour urine collections were analysed for catecholamines before and after treatment with continuous positive airways pressure (CPAP).<p...

Obstructive sleep apnoea (OSA)is associated with increased cardiovascular morbidity and mortality and is an independent risk factor for the development of hypertension. A recent study demonstrated elevated urinary catecholamine excretion in hypertensive males with OSA. However, we have recently observed the phenomenum whereby OSA can rarely induce catecholamine production of sufficient severity to mimic the clinical and biochemical presentation of phaeochromocytoma.<p clas...

Obstructive sleep apnoea (OSA)is associated with increased cardiovascular morbidity and mortality and is an independent risk factor for the development of hypertension. A recent study demonstrated elevated urinary catecholamine excretion in hypertensive males with OSA. However, we have recently observed the phenomenum whereby OSA can rarely induce catecholamine production of sufficient severity to mimic the clinical and biochemical presentation of phaeochromocytoma.<p clas...